The median home value in Port St Lucie, FL is $410,000. The national median home value is $338,100. The average price of homes sold in Port St Lucie, FL is $410,000. Port St Lucie real estate listings include condos, townhomes, and single family homes for sale. Commercial properties are also available. If you see a property you’re interested in, contact a Port St Lucie real estate agent to arrange a tour today!